{"title":"PDRN Skincare","description":"\u003cp\u003e\u003cstrong\u003ePDRN\u003c\/strong\u003e (polydeoxyribonucleotide) is a mix of DNA fragments, usually taken from salmon. In medicine it is injected to support wound healing and tissue repair; in Korean skincare it has become one of the most popular new ingredients, listed on the label as sodium DNA. Here you can buy PDRN skincare in Switzerland, from a hydrogel mask and eye patches to a retinal ampoule, a toner and a sun spray.\u003c\/p\u003e\n\u003cp\u003eMost products list PDRN in tiny amounts, so I judge each one by its whole formula, not by the PDRN alone.\u003c\/p\u003e","products":[{"product_id":"pdrn-pink-collagen-gel-mask","title":"PDRN Pink Collagen Gel Mask","description":"\u003cp\u003eThe \u003cstrong\u003eMedicube PDRN Pink Collagen Gel Mask\u003c\/strong\u003e is an intensive hydrogel treatment designed to improve hydration, skin plumpness and overall radiance. Its formula combines \u003cstrong\u003ePDRN (Sodium DNA), hydrolyzed collagen, niacinamide and a multi-peptide complex\u003c\/strong\u003e in a hydrogel mask that gradually becomes transparent as it is worn.\u003c\/p\u003e\n\u003cp\u003eFrom a medical skincare perspective, \u003cstrong\u003ePDRN\u003c\/strong\u003e is an interesting ingredient with an established role in regenerative medicine, although the evidence for topically applied PDRN is considerably more limited than for injectable treatments. In this mask, \u003cstrong\u003eSodium DNA is present at 3 ppm\u003c\/strong\u003e, so I consider it a supportive skin-conditioning ingredient rather than a substitute for professional PDRN procedures.\u003c\/p\u003e\n\u003cp\u003eThe formula also contains \u003cstrong\u003ehydrolyzed collagen (300 ppm)\u003c\/strong\u003e. Topical collagen does not replace collagen within the dermis; instead, hydrolyzed collagen primarily contributes to surface hydration and film formation, helping the skin feel softer, smoother and temporarily more plumped.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eNiacinamide\u003c\/strong\u003e is one of the most relevant active ingredients in the formula. This well-studied form of vitamin B3 supports epidermal barrier function and can help improve uneven pigmentation, skin tone and overall radiance.\u003c\/p\u003e\n\u003cp\u003eThe mask is further enriched with an extensive \u003cstrong\u003epeptide complex\u003c\/strong\u003e, including Copper Tripeptide-1, Palmitoyl Pentapeptide-4 and several acetylated peptides, together with \u003cstrong\u003eadenosine\u003c\/strong\u003e for additional skin-conditioning and anti-aging support.\u003c\/p\u003e\n\u003cp\u003eHumectants including \u003cstrong\u003eglycerin, betaine and glycols\u003c\/strong\u003e, together with \u003cstrong\u003epanthenol and allantoin\u003c\/strong\u003e, help replenish moisture and maintain skin comfort. The hydrogel format creates an occlusive environment that reduces evaporation while the mask is worn, allowing the skin to become intensely hydrated.\u003c\/p\u003e\n\u003cp\u003eAfter application, the complexion appears \u003cstrong\u003eplumper, smoother and more luminous\u003c\/strong\u003e, with fine dehydration lines temporarily softened and the skin feeling deeply moisturized.\u003c\/p\u003e\n\u003ch3\u003eKey Benefits\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eProvides intensive, long-lasting \u003cstrong\u003ehydration\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli\u003eCreates an immediate \u003cstrong\u003eplumping and smoothing effect\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli\u003eHydrolyzed collagen supports surface hydration and suppleness\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eHelps improve the appearance of dull, tired and dehydrated skin\u003c\/li\u003e\n\u003cli\u003eHydrogel technology supports prolonged contact with the essence\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eIdeal For\u003c\/h3\u003e\n\u003cp\u003eDehydrated and dry skin, dull or tired-looking complexions, fine dehydration lines, loss of suppleness and skin requiring an intensive hydrating treatment.\u003c\/p\u003e\n\u003cp\u003eFor more intensive care, the mask can be worn for \u003cstrong\u003e2–4 hours\u003c\/strong\u003e. According to the manufacturer's instructions, it can also be used overnight and removed the following morning.\u003c\/p\u003e","brand":"MEDICUBE","offers":[{"title":"Default Title","offer_id":58560429556086,"sku":null,"price":3.7,"currency_code":"CHF","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0771\/6981\/9922\/files\/MEDICUBEPDRNPinkCollagenGelMask-00_490x510_crop_center_1fb56968-a0af-47cd-8235-2b8ffd666712.png?v=1787993663"},{"product_id":"caviar-pdrn-eye-patches","title":"Caviar PDRN Eye Patches","description":"\u003cp\u003e\u003cstrong\u003eBiodance Caviar PDRN Eye Patches\u003c\/strong\u003e are cooling hydrogel patches for tired-looking, puffy or dry under-eyes. I suggest them for mornings after a short night, before an event, or as a small weekly ritual. One jar holds 30 pairs.\u003c\/p\u003e\n\u003cp\u003eThe essence is based on glycerin and caviar water (about 10.8%, according to the label), with niacinamide, betaine, trehalose, adenosine and caffeine. PDRN is listed as sodium DNA at 1 ppm, which is a very small amount. The patches contain caviar extract, salmon egg extract and carmine, so they are not vegan. No fragrance is listed.\u003c\/p\u003e\n\u003cdiv style=\"background:#f2e9e1;border-left:4px solid #f04557;padding:20px 22px;margin:24px 0;\"\u003e\n\u003ch3 style=\"margin:0 0 14px;\"\u003e🔬 How long should you leave patches on?\u003c\/h3\u003e\n\u003cdiv style=\"display:flex;flex-wrap:wrap;gap:10px;margin:0 0 14px;\"\u003e\n\u003cdiv style=\"flex:1 1 0;min-width:0;background:#fffaf6;padding:10px 8px;text-align:center;\"\u003e\n\u003cspan style=\"display:block;font-size:1.3em;font-weight:600;color:#f04557;line-height:1.15;\"\u003e35\u003c\/span\u003e\u003cspan style=\"display:block;font-size:0.78em;line-height:1.3;color:#2d231f;\"\u003eadults in the timing test\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"flex:1 1 0;min-width:0;background:#fffaf6;padding:10px 8px;text-align:center;\"\u003e\n\u003cspan style=\"display:block;font-size:1.3em;font-weight:600;color:#f04557;line-height:1.15;\"\u003e5–30\u003c\/span\u003e\u003cspan style=\"display:block;font-size:0.78em;line-height:1.3;color:#2d231f;\"\u003eminutes tested\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"flex:1 1 0;min-width:0;background:#fffaf6;padding:10px 8px;text-align:center;\"\u003e\n\u003cspan style=\"display:block;font-size:1.3em;font-weight:600;color:#f04557;line-height:1.15;\"\u003e\u0026lt;20\u003c\/span\u003e\u003cspan style=\"display:block;font-size:0.78em;line-height:1.3;color:#2d231f;\"\u003eminutes recommended\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp style=\"margin:0;\"\u003eResearchers in China measured how much of a sheet mask's essence actually ends up on the skin. In 35 people who wore the same mask for 5 to 30 minutes, the amount taken up grew with time and rose sharply from 25 minutes on, so the authors recommend keeping a mask on for less than 20 minutes.\u003csup\u003e1\u003c\/sup\u003e The study tested face sheet masks, not eye patches, and it measured exposure, not how the skin looked afterwards. Still, it supports a simple rule for patches too: 15 to 20 minutes is enough, and longer is not automatically better.\u003c\/p\u003e\n\u003cp style=\"font-size:0.8em;color:#8a6f65;border-top:1px solid #e7cace;padding-top:10px;margin:10px 0 0;\"\u003e1. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35075174\/\" target=\"_blank\" rel=\"noopener\" style=\"color:#8a6f65;\"\u003eZhou L, Chen J, Chen T, et al. Investigation of actual exposure to facial sheet mask preceding its risk assessment. Sci Rep. 2022;12. doi:10.1038\/s41598-022-05351-3\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003ch3\u003eQuestions about Biodance Caviar PDRN Eye Patches\u003c\/h3\u003e\n\u003cdetails style=\"border-bottom:1px solid #e7ded7;padding:10px 0;\"\u003e\u003csummary style=\"font-weight:600;cursor:pointer;\"\u003eDo they help against dark circles?\u003c\/summary\u003e\u003cp style=\"margin:8px 0 0;\"\u003eThey can make the area look fresher and less puffy for a few hours, mainly through cooling and moisture. Dark circles caused by pigment, thin skin or genetics need other care. Daily sunscreen and enough sleep help most.\u003c\/p\u003e\u003c\/details\u003e\n\u003cdetails style=\"border-bottom:1px solid #e7ded7;padding:10px 0;\"\u003e\u003csummary style=\"font-weight:600;cursor:pointer;\"\u003eHow often can I use them?\u003c\/summary\u003e\u003cp style=\"margin:8px 0 0;\"\u003eUp to once a day. Always use the spatula, close the jar tightly and store it in a cool place. Straight from the fridge, they feel even more cooling.\u003c\/p\u003e\u003c\/details\u003e\n\u003cdetails style=\"border-bottom:1px solid #e7ded7;padding:10px 0;\"\u003e\u003csummary style=\"font-weight:600;cursor:pointer;\"\u003eCan I use them with an eye cream?\u003c\/summary\u003e\u003cp style=\"margin:8px 0 0;\"\u003eYes. Use the patches first, pat in the remaining essence, then apply your eye cream.\u003c\/p\u003e\u003c\/details\u003e\n\u003cp style=\"margin-top:20px;\"\u003eTo compare, have a look at the \u003ca href=\"\/products\/bean-hydrogel-eye-patch\"\u003eMIXSOON Bean Hydrogel Eye Patch\u003c\/a\u003e, see my \u003ca href=\"\/collections\/eye-care\"\u003eeye care\u003c\/a\u003e selection, or all \u003ca href=\"\/collections\/masks-and-treatments\"\u003eface masks\u003c\/a\u003e.\u003c\/p\u003e","brand":"BIODANCE","offers":[{"title":"Default Title","offer_id":59327493112182,"sku":null,"price":24.9,"currency_code":"CHF","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0771\/6981\/9922\/files\/biodance-caviar-pdrn-eye-patches-transparent.png?v=1794512342"},{"product_id":"no-9-nad-pdrn-glow-lock-sun-spray-spf50-pa","title":"No.9 NAD+ PDRN Glow Lock Sun Spray SPF50+ PA++++","description":"\u003cp\u003e\u003cstrong\u003eNumbuzin No.9 NAD+ PDRN Glow Lock Sun Spray SPF50+ PA++++\u003c\/strong\u003e is a light Korean sun spray for topping up your protection during the day, also over make-up. I suggest it as a practical second step: apply your usual sunscreen in the morning and use this spray to reapply when you are out.\u003c\/p\u003e\u003cp\u003eIt gives a fine, dewy mist with a glowy finish. It protects with chemical (organic) UV filters only, including modern broad-spectrum filters such as bemotrizinol, and also contains niacinamide, NAD+, PDRN (sodium DNA) and a long list of peptides as skin-conditioning extras. You can find the full list in the ingredients section. Sprays are easy to use, but it is also easy to apply too little: spray generously, in several passes, and pat it in.\u003c\/p\u003e\u003cdiv style=\"background:#f2e9e1;border-left:4px solid #f04557;padding:20px 22px;margin:24px 0;\"\u003e\n\u003ch3 style=\"margin:0 0 14px;\"\u003e🔬 Does sunscreen really prevent skin aging?\u003c\/h3\u003e\n\u003cdiv style=\"display:flex;flex-wrap:wrap;gap:10px;margin:0 0 14px;\"\u003e\n\u003cdiv style=\"flex:1 1 0;min-width:0;background:#fffaf6;padding:10px 8px;text-align:center;\"\u003e\n\u003cspan style=\"display:block;font-size:1.3em;font-weight:600;color:#f04557;line-height:1.15;\"\u003e903\u003c\/span\u003e\u003cspan style=\"display:block;font-size:0.78em;line-height:1.3;color:#2d231f;\"\u003eadults in the trial\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"flex:1 1 0;min-width:0;background:#fffaf6;padding:10px 8px;text-align:center;\"\u003e\n\u003cspan style=\"display:block;font-size:1.3em;font-weight:600;color:#f04557;line-height:1.15;\"\u003e4.5\u003c\/span\u003e\u003cspan style=\"display:block;font-size:0.78em;line-height:1.3;color:#2d231f;\"\u003eyears of daily use\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"flex:1 1 0;min-width:0;background:#fffaf6;padding:10px 8px;text-align:center;\"\u003e\n\u003cspan style=\"display:block;font-size:1.3em;font-weight:600;color:#f04557;line-height:1.15;\"\u003e24%\u003c\/span\u003e\u003cspan style=\"display:block;font-size:0.78em;line-height:1.3;color:#2d231f;\"\u003eless skin aging\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp style=\"margin:0;\"\u003eIn a randomised trial in Australia, adults under 55 who used sunscreen every day showed 24% less skin aging after 4.5 years than those who used it only when they felt like it.\u003csup\u003e1\u003c\/sup\u003e It is one trial, done in a very sunny place, but it is large and long, which is rare in skincare research. The important word is \u003cem\u003edaily\u003c\/em\u003e: a texture you enjoy is what makes daily use realistic.\u003c\/p\u003e\n\u003cp style=\"font-size:0.8em;color:#8a6f65;border-top:1px solid #e7cace;padding-top:10px;margin:10px 0 0;\"\u003e1. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23732711\/\" target=\"_blank\" rel=\"noopener\" style=\"color:#8a6f65;\"\u003eHughes MCB, Williams GM, Baker P, Green AC. Sunscreen and prevention of skin aging: a randomized trial. Ann Intern Med. 2013;158(11):781–790.\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\u003ch3\u003eQuestions about Numbuzin No.9 NAD+ PDRN Glow Lock Sun Spray\u003c\/h3\u003e\u003cdetails style=\"border-bottom:1px solid #e7ded7;padding:10px 0;\"\u003e\u003csummary style=\"font-weight:600;cursor:pointer;\"\u003eCan I use it as my only sunscreen?\u003c\/summary\u003e\u003cp style=\"margin:8px 0 0;\"\u003eFor the face, a cream or fluid makes it easier to apply the right amount. I recommend this spray mainly for reapplying during the day.\u003c\/p\u003e\u003c\/details\u003e\u003cdetails style=\"border-bottom:1px solid #e7ded7;padding:10px 0;\"\u003e\u003csummary style=\"font-weight:600;cursor:pointer;\"\u003eHow do I use it over make-up?\u003c\/summary\u003e\u003cp style=\"margin:8px 0 0;\"\u003eShake well, close your eyes and mouth, hold the spray 15–20 cm from your face and spray evenly in several passes. Let it dry, and avoid breathing in the mist.\u003c\/p\u003e\u003c\/details\u003e\u003cdetails style=\"border-bottom:1px solid #e7ded7;padding:10px 0;\"\u003e\u003csummary style=\"font-weight:600;cursor:pointer;\"\u003eHow often should I reapply?\u003c\/summary\u003e\u003cp style=\"margin:8px 0 0;\"\u003eEvery 2 hours in the sun, and after sweating, swimming or towelling off.\u003c\/p\u003e\u003c\/details\u003e\u003cp style=\"margin-top:20px;\"\u003eTo compare, have a look at the \u003ca href=\"\/products\/ultra-light-invisible-sunscreen-spf50-pa\"\u003eCOSRX Ultra-Light Invisible Sunscreen SPF50 PA++++\u003c\/a\u003e, see my full \u003ca href=\"\/collections\/sun-protection-all\"\u003esun protection\u003c\/a\u003e selection, or all \u003ca href=\"\/collections\/aging\"\u003eanti-aging skincare\u003c\/a\u003e.\u003c\/p\u003e","brand":"NUMBUZIN","offers":[{"title":"Default Title","offer_id":59327605703030,"sku":null,"price":21.9,"currency_code":"CHF","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0771\/6981\/9922\/files\/numbuzin-no9-nad-pdrn-glow-lock-sun-spray-transparent.png?v=1794512343"},{"product_id":"tuliprx-pdrn-retinal-night-cell-ampoule","title":"TulipRx PDRN Retinal Night Cell Ampoule","description":"\u003cp\u003e\u003cstrong\u003eApothe TulipRx PDRN Retinal Night Cell Ampoule\u003c\/strong\u003e is a Korean night ampoule with retinal, a fast-acting form of vitamin A, combined with PDRN and a tulip extract complex. I suggest it for fine lines, rough texture, enlarged-looking pores and an uneven tone, if you already know retinol or would like a small, concentrated bottle for the evening.\u003c\/p\u003e\u003cp\u003eRetinal (retinaldehyde) is one step closer than retinol to retinoic acid, the form the skin actually uses, so it usually works a little faster and can also irritate a little more. The small 14 ml bottle is used drop by drop. Apothe does not publish the retinal percentage. In the ingredient list, retinal comes after the thickeners, which fits the low amounts in which retinal is normally used. The formula also contains panthenol, niacinamide and ectoin to support the skin barrier. You can find the full list in the ingredients section. Start slowly, two to three evenings a week, and always wear sunscreen during the day.\u003c\/p\u003e\u003cdiv style=\"background:#f2e9e1;border-left:4px solid #f04557;padding:20px 22px;margin:24px 0;\"\u003e\n\u003ch3 style=\"margin:0 0 14px;\"\u003e🔬 Does vitamin A skincare really work on fine lines?\u003c\/h3\u003e\n\u003cdiv style=\"display:flex;flex-wrap:wrap;gap:10px;margin:0 0 14px;\"\u003e\n\u003cdiv style=\"flex:1 1 0;min-width:0;background:#fffaf6;padding:10px 8px;text-align:center;\"\u003e\n\u003cspan style=\"display:block;font-size:1.3em;font-weight:600;color:#f04557;line-height:1.15;\"\u003e62\u003c\/span\u003e\u003cspan style=\"display:block;font-size:0.78em;line-height:1.3;color:#2d231f;\"\u003eadults with sun-aged skin\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"flex:1 1 0;min-width:0;background:#fffaf6;padding:10px 8px;text-align:center;\"\u003e\n\u003cspan style=\"display:block;font-size:1.3em;font-weight:600;color:#f04557;line-height:1.15;\"\u003e52\u003c\/span\u003e\u003cspan style=\"display:block;font-size:0.78em;line-height:1.3;color:#2d231f;\"\u003eweeks of 0.1% retinol\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"flex:1 1 0;min-width:0;background:#fffaf6;padding:10px 8px;text-align:center;\"\u003e\n\u003cspan style=\"display:block;font-size:1.3em;font-weight:600;color:#f04557;line-height:1.15;\"\u003e44%\u003c\/span\u003e\u003cspan style=\"display:block;font-size:0.78em;line-height:1.3;color:#2d231f;\"\u003eimprovement in crow's feet lines\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp style=\"margin:0;\"\u003eIn a one-year double-blind study, 62 adults used either a cream with 0.1% stabilised retinol or the same cream without retinol on the whole face. The retinol group improved more than the comparison group at every check-up, and after 52 weeks fine lines around the eyes had improved by 44% and blotchy pigmentation by 84%.\u003csup\u003e1\u003c\/sup\u003e To be honest, the evidence is weaker than these numbers suggest: the study tested retinol, not retinal, in a different cream, and a 2021 review of nine such retinol trials found that almost all were paid for by the product makers and that the overall proof is weak.\u003csup\u003e2\u003c\/sup\u003e Retinal works on the same pathway, so I see this ampoule as a realistic long-term helper that needs months of regular use, always with daily sunscreen.\u003c\/p\u003e\n\u003cp style=\"font-size:0.8em;color:#8a6f65;border-top:1px solid #e7cace;padding-top:10px;margin:10px 0 0;\"\u003e1. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25738849\/\" target=\"_blank\" rel=\"noopener\" style=\"color:#8a6f65;\"\u003eRandhawa M, Rossetti D, Leyden JJ, et al. One-year topical stabilized retinol treatment improves photodamaged skin in a double-blind, vehicle-controlled trial. J Drugs Dermatol. 2015;14(3):271–276.\u003c\/a\u003e\u003cbr\u003e2. \u003ca href=\"https:\/\/jcadonline.com\/efficacy-of-over-the-counter-vitamin-a\/\" target=\"_blank\" rel=\"noopener\" style=\"color:#8a6f65;\"\u003eSpierings NMK. Evidence for the efficacy of over-the-counter vitamin A cosmetic products in the improvement of facial skin aging: a systematic review. J Clin Aesthet Dermatol. 2021;14(9):33–40.\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\u003ch3\u003eQuestions about Apothe TulipRx PDRN Retinal Night Cell Ampoule\u003c\/h3\u003e\u003cdetails style=\"border-bottom:1px solid #e7ded7;padding:10px 0;\"\u003e\u003csummary style=\"font-weight:600;cursor:pointer;\"\u003eCan I use it during pregnancy?\u003c\/summary\u003e\u003cp style=\"margin:8px 0 0;\"\u003eNo. It contains retinal, a form of vitamin A. I recommend avoiding retinoid skincare during pregnancy.\u003c\/p\u003e\u003c\/details\u003e\u003cdetails style=\"border-bottom:1px solid #e7ded7;padding:10px 0;\"\u003e\u003csummary style=\"font-weight:600;cursor:pointer;\"\u003eHow do I start?\u003c\/summary\u003e\u003cp style=\"margin:8px 0 0;\"\u003eTwo to three evenings a week: 2–3 drops on dry skin after cleansing, then moisturiser. If your skin stays calm for two weeks, increase slowly. Some dryness or flaking in the first weeks is normal; redness and burning are a sign to slow down.\u003c\/p\u003e\u003c\/details\u003e\u003cdetails style=\"border-bottom:1px solid #e7ded7;padding:10px 0;\"\u003e\u003csummary style=\"font-weight:600;cursor:pointer;\"\u003eCan I combine it with vitamin C or acids?\u003c\/summary\u003e\u003cp style=\"margin:8px 0 0;\"\u003eNot in the same routine. Use vitamin C in the morning and this ampoule in the evening, and skip exfoliating acids on retinal nights.\u003c\/p\u003e\u003c\/details\u003e\u003cp style=\"margin-top:20px;\"\u003eFor a gentler start, have a look at the \u003ca href=\"\/products\/hyper-retinol-ex-1-0-serum\"\u003eISNTREE Hyper Retinol EX 1.0 Serum\u003c\/a\u003e, see my full \u003ca href=\"\/collections\/retinols\"\u003eretinol \u0026amp; retinal\u003c\/a\u003e selection, or all \u003ca href=\"\/collections\/aging\"\u003eanti-aging skincare\u003c\/a\u003e.\u003c\/p\u003e","brand":"APOTHE","offers":[{"title":"Default Title","offer_id":59327712821622,"sku":null,"price":24.9,"currency_code":"CHF","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0771\/6981\/9922\/files\/apothe-tuliprx-pdrn-retinal-night-cell-ampoule-transparent.png?v=1794512343"},{"product_id":"tuliprx-pdrn-hydro-capsule-shot-essence-toner","title":"TulipRx PDRN Hydro Capsule Shot Essence Toner","description":"\u003cp\u003e\u003cstrong\u003eApothe TulipRx PDRN Hydro Capsule Shot Essence Toner\u003c\/strong\u003e is a Korean essence toner with tiny capsules, PDRN and a tulip extract complex. I suggest it as a hydrating first step after cleansing for dry, dehydrated or dull-looking skin, and for anyone who likes to layer a toner before serum.\u003c\/p\u003e\u003cp\u003eThe ingredient list shows where the ‘shot’ comes from: hydrolysed sponge, tiny natural sponge needles (spicules) that can make the skin tingle for a few minutes. It also contains small amounts of three exfoliating acids (glycolic acid, salicylic acid and gluconolactone), plus niacinamide, panthenol and PDRN (sodium DNA), a DNA-based ingredient that is very popular in Korean skincare at the moment. Because of the spicules, I do not recommend it for very sensitive or irritated skin or rosacea. You can find the full list in the ingredients section.\u003c\/p\u003e\u003cdiv style=\"background:#f2e9e1;border-left:4px solid #f04557;padding:20px 22px;margin:24px 0;\"\u003e\n\u003ch3 style=\"margin:0 0 14px;\"\u003e🔬 What does PDRN in skincare really do?\u003c\/h3\u003e\n\u003cdiv style=\"display:flex;flex-wrap:wrap;gap:10px;margin:0 0 14px;\"\u003e\n\u003cdiv style=\"flex:1 1 0;min-width:0;background:#fffaf6;padding:10px 8px;text-align:center;\"\u003e\n\u003cspan style=\"display:block;font-size:1.3em;font-weight:600;color:#f04557;line-height:1.15;\"\u003e50–1,500\u003c\/span\u003e\u003cspan style=\"display:block;font-size:0.78em;line-height:1.3;color:#2d231f;\"\u003ekDa: size of PDRN molecules\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"flex:1 1 0;min-width:0;background:#fffaf6;padding:10px 8px;text-align:center;\"\u003e\n\u003cspan style=\"display:block;font-size:1.3em;font-weight:600;color:#f04557;line-height:1.15;\"\u003eA2A\u003c\/span\u003e\u003cspan style=\"display:block;font-size:0.78em;line-height:1.3;color:#2d231f;\"\u003ethe cell receptor PDRN acts on\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"flex:1 1 0;min-width:0;background:#fffaf6;padding:10px 8px;text-align:center;\"\u003e\n\u003cspan style=\"display:block;font-size:1.3em;font-weight:600;color:#f04557;line-height:1.15;\"\u003eSalmon\u003c\/span\u003e\u003cspan style=\"display:block;font-size:0.78em;line-height:1.3;color:#2d231f;\"\u003eDNA source of medical PDRN\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp style=\"margin:0;\"\u003ePDRN is a mixture of DNA fragments, usually from salmon, and is also registered as a medicine. A 2017 review describes its repairing and anti-inflammatory effects, mainly through the adenosine A2A receptor, in wound healing and regenerative medicine.\u003csup\u003e1\u003c\/sup\u003e The molecules are large, between 50 and 1,500 kDa, and a 2026 study points out that this size limits how well PDRN can pass the skin barrier on its own.\u003csup\u003e2\u003c\/sup\u003e So, to be honest: in a toner, PDRN works mainly on the skin surface, and the hydration you feel comes largely from the moisturising ingredients. I see it as a nice extra, not a reason on its own to buy a product.\u003c\/p\u003e\n\u003cp style=\"font-size:0.8em;color:#8a6f65;border-top:1px solid #e7cace;padding-top:10px;margin:10px 0 0;\"\u003e1. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28491036\/\" target=\"_blank\" rel=\"noopener\" style=\"color:#8a6f65;\"\u003eSquadrito F, Bitto A, Irrera N, et al. Pharmacological activity and clinical use of PDRN. Front Pharmacol. 2017;8:224.\u003c\/a\u003e\u003cbr\u003e2. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42789403\/\" target=\"_blank\" rel=\"noopener\" style=\"color:#8a6f65;\"\u003eCho J, Han D, Lee H, Park DW. Numerical simulation of PDRN iontophoresis: comparison with passive diffusion and key parameter analysis. Drug Deliv. 2026;33(1):2726625.\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\u003ch3\u003eQuestions about Apothe TulipRx PDRN Hydro Capsule Shot Essence Toner\u003c\/h3\u003e\u003cdetails style=\"border-bottom:1px solid #e7ded7;padding:10px 0;\"\u003e\u003csummary style=\"font-weight:600;cursor:pointer;\"\u003eToner or essence?\u003c\/summary\u003e\u003cp style=\"margin:8px 0 0;\"\u003eBoth: it is a watery first step after cleansing that hydrates more than a classic toner, so you can use it instead of, or before, an essence.\u003c\/p\u003e\u003c\/details\u003e\u003cdetails style=\"border-bottom:1px solid #e7ded7;padding:10px 0;\"\u003e\u003csummary style=\"font-weight:600;cursor:pointer;\"\u003eHow do I use it?\u003c\/summary\u003e\u003cp style=\"margin:8px 0 0;\"\u003ePump 2–3 times into your palms or onto a cotton pad and gently press it into your face and neck. A light tingling is normal; if it burns, rinse it off with water.\u003c\/p\u003e\u003c\/details\u003e\u003cdetails style=\"border-bottom:1px solid #e7ded7;padding:10px 0;\"\u003e\u003csummary style=\"font-weight:600;cursor:pointer;\"\u003eCan I use it with retinol?\u003c\/summary\u003e\u003cp style=\"margin:8px 0 0;\"\u003eCarefully. The spicules and the light acids can make retinoids feel stronger. If your skin is new to retinol or easily irritated, use this toner in the morning and your retinol in the evening.\u003c\/p\u003e\u003c\/details\u003e\u003cp style=\"margin-top:20px;\"\u003eTo compare, have a look at the \u003ca href=\"\/products\/milk-skin-toner-1\"\u003eTIRTIR Milk Skin Toner\u003c\/a\u003e, see all my \u003ca href=\"\/collections\/toners\"\u003etoners and essences\u003c\/a\u003e, or my selection for \u003ca href=\"\/collections\/dry-skin\"\u003edry and dehydrated skin\u003c\/a\u003e.\u003c\/p\u003e","brand":"APOTHE","offers":[{"title":"Default Title","offer_id":59327712854390,"sku":null,"price":24.9,"currency_code":"CHF","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0771\/6981\/9922\/files\/apothe-tuliprx-pdrn-hydro-capsule-shot-essence-toner-transparent.png?v=1794512344"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0771\/6981\/9922\/collections\/BiodanceCaviarPDRNEyePatch85g30pairs-2.jpg?v=1794514224","url":"https:\/\/moreaboutskin.ch\/collections\/pdrn.oembed","provider":"More about Skin","version":"1.0","type":"link"}